Adspire are Conscious who were once born in DD but then transferred over to Reality. There are two ways that can happen. The first is that this Conscious died and an unsuspecting newbie came to take take up residence in the Dimension and their Consciouses became tangled and the newbie became the previously dead Conscious. (This isn't as uncommon as it may sound. These Conscious tend to be Adspires and Telepaths).

Another way is that Conscious use portals to escape DD in a sense, and these Conscious end up paying the price with mental disabilities.